Protein dynamics under realistic conditions
Sept. 26, 2021 - Highlight from research: Influence of "crowding" in the cell
| In a study published in J. Phys. Chem. Lett. a collaboration from Tübingen, Grenoble, Dublin and Lund shows the influence of the high proportion of macromolecular components ("crowding") on the diffusion of proteins. Using a model system that simulates the situation in a living cell, the dependence of diffusion on the polydispersity of the macromolecular components in particular can be better understood. The key to this understanding lies in the combination of high-resolution neutron spectroscopy ("quasi-elastic neutron scattering" in backscattering geometry) and complex computer simulations. M. Grimaldo et al., J. Phys. Chem. Lett. 10 (2019), 1709, https://dx.doi.org/10.1021/acs.jpclett.9b00345 M. Grimaldo et al., Quart. Rev. Biophys. 52 (2019), e7, 1, https://dx.doi.org/10.1017/S0033583519000027 |